Projects 9031-9039 moving to advanced

[sryckbos]

Hey everyone,

Projects 9031-9039 (which are just continuations of projects 9021-9029) are going into advanced on my new work server. I know there is high unmet demand for CPU jobs right now so I'm hoping there will be no problems on advanced and I'll be able to get these projects into full fah so you guys can get some new WUs. Sorry about the delay, we should be up there very soon.

Steven

Stats:
Project 9031-9039
Deadline: 8.32
Timeout: 3.84
Stats Credit: 207

Project Description:
Bryostatin is a marine natural product that shows promising and unique activity against several diseases (most notably, cancer, HIV/AIDS, and Alzheimer’s). Its main target, protein kinase C (PKC), is a signaling protein central to many cellular functions. In its active form, PKC binds its ligand and is associated with the membrane, but we currently lack structural information about this complex in its membrane microenvironment. The simulations performed on FAH will help to provide a structure to the PKC-ligand-membrane complex. The structure and dynamics of this complex would allow us to understand bryostatin’s binding mode and thus how to modify and tune its structure to improve function or even create new functions as needed for new therapies in the clinic.

All three operating systems should be supported. These jobs will run on systems with 1-24 processors. Please let me know if there are any issues.