Exactly .Nert wrote:Thanks for this link. As a layman I found it mostly understandable. I think that I now understand the difference between Alpha Fold and FAH: Alpha Fold predicts what a protein will look like after it's folded. FAH determines the individual steps a protein goes through to get to that final shape.
For the specific example of COVID19, there's a vulnerable "mouth" under the head of the "spike" which "opens up" periodically that can be attacked by specific protein fragments, but it's closed most of the time. There are pictures of that process in some of FAH's associated supporting documentation that works for a layman like myself.
Finding the final shape is still an important goal for many scientific studies -- but from my perspective, that's the easy part. I really appreciate the finger-shadow-puppet description of X-ray chrystolography. It is a great way to describe the traditional methodology to the layman.