Folding Forum

Protein phosphatase 2A (PP2A) mutations have been linked to intellectual disability and cancer, potentially disrupting the protein’s autoinhibition mechanism and phosphorylation-induced activation. The mutations are located distant from the active and substrate sites, their impact on the mechanism r...

Protein phosphatase 2A (PP2A) mutations have been linked to intellectual disability and cancer, potentially disrupting the protein’s autoinhibition mechanism and phosphorylation-induced activation. The mutations are located distant from the active and substrate sites, their impact on the mechanism r...