Search found 4 matches

by fibonacci
Sun Nov 16, 2014 11:53 pm
Forum: The Science of FAH -- questions/answers
Topic: Protein folding: you'll never solve it without the Glycome
Replies: 6
Views: 3753

Re: Protein folding: you'll never solve it without the Glyco

The Glycome is clearly important, but one can come up with drugs for cancer, Alzheimers', infectious disease, and many other areas w/o having to address it. So why get more complex than you have to in order to solve these key problems. I'm sure it's something that we'll get involved with sooner or ...
by fibonacci
Sun Nov 16, 2014 4:44 pm
Forum: The Science of FAH -- questions/answers
Topic: Protein folding: you'll never solve it without the Glycome
Replies: 6
Views: 3753

Re: Protein folding: you'll never solve it without the Glyco

Folding@home has also produced several paper on proteins folding in a crowded and complex environment. I agree with Bruce that there's plenty to to with molecules/proteins in solution, but things get even more complex if you bring other molecules into the picture. This has something that has been s...
by fibonacci
Sun Nov 16, 2014 4:26 pm
Forum: The Science of FAH -- questions/answers
Topic: Protein folding: you'll never solve it without the Glycome
Replies: 6
Views: 3753

Re: Protein folding: you'll never solve it without the Glyco

The ultimate goal of protein folding is probably, I'm guessing, the ability to predict function from form, and this is where things are not straightforward at all. Bad guess. Have you read any of the technical papers that have been published based on FAH's research? See http://folding.stanford.edu/...
by fibonacci
Sun Nov 16, 2014 12:34 am
Forum: The Science of FAH -- questions/answers
Topic: Protein folding: you'll never solve it without the Glycome
Replies: 6
Views: 3753

Protein folding: you'll never solve it without the Glycome

Why is it that the vast majority of thinking about the protein folding problem seems to be overly reductionist in its approach? What seems to be massively overlooked is that fact that many proteins are not just proteins, but rather they're GLYCOproteins. We now know that glycosylation of proteins ha...